Molecular Mechanisms of Topography Sensing by Osteoblasts: An Update

Bone is a specialized tissue formed by different cell types and multiscale, complex mineralized matrix. The architecture the surface chemistry of this microenvironment can be factors considerable influence on biology, affect proliferation, commitment to differentiation, gene expression, matrix production and/or composition. It has been shown that osteoblasts encounter natural motifs in vivo, with various topographies (shapes, sizes, organization), cultures flat surfaces do not reflect total potential tissue. Therefore, studies investigating role behavior are important order better understand interaction between cells surfaces, improve osseointegration processes vivo tissues biomaterials, find topographic enhance bone repair. In review, we evaluate main available data about topographies, techniques for topographies’ production, mechanical signal transduction from impact cell–surface interactions or preosteoblasts’ behavior.